Even after weight loss, the risk of developing obesity-related diseases – such as Type 2 Diabetes and some forms of cancer – can persist for years, according to a new scientific study.
Research conducted by the University of Birmingham shows that obesity leaves a long-term "imprint" on immune cells, affecting their function even after the individual has lost weight. According to the researchers, the body can "remember" the effects of obesity for a period of 5 to 10 years.
This phenomenon is related to a process called DNA methylation, which causes changes in immune cells (CD4+ lymphocytes), affecting their ability to protect the body and clear metabolic waste. As a result, the risk of complications such as metabolic diseases and cancer remains present even after weight loss.
Professor Claudio Mauro stresses that short-term weight loss may not be enough to immediately reduce the risk of these diseases, suggesting that maintaining a healthy weight over the long term is essential.
The study analyzed blood samples from different groups of individuals over a 10-year period, including people who had used weight-loss treatments, as well as cases with genetic disorders linked to obesity. It also studied experimental models to better understand the impact of high-fat diets.
Experts suggest that these findings could pave the way for new treatments, including the use of drugs that help improve immune system function.
Obesity remains a growing global problem, affecting over a billion people worldwide. It is linked to a range of serious health complications, including heart disease, breast and colon cancer, and stroke.
Experts emphasize the importance of a healthy and sustainable lifestyle in the long term, including balanced nutrition and physical activity, as the most effective way to reduce the risks associated with obesity. /GazetaExpress/
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