A new, non-hormonal treatment is being considered as a promising alternative for women who suffer from hot flashes and night sweats during menopause, especially those who cannot or do not want to use hormone replacement therapy (HRT).
The new drug, fezolinetant (known as Veozah), works differently from HRT. Instead of replacing hormones, it affects the brain centers that regulate body temperature, blocking the nerve signals that cause these symptoms.
According to clinical studies involving about 400 women aged 40–65, the treatment resulted in significant symptom relief within a few days or weeks, with minimal side effects. Experts consider this development a significant change in the treatment of menopause.
Around 500 women could benefit from the drug, which has been approved for use in England's public health system for cases where HRT is not suitable. Traditional hormone therapies can increase the risk of blood clots and are not recommended for women at high risk of thrombosis or heart disease.
However, the new drug is not without its limitations. It only treats some symptoms of menopause and does not offer the protection that HRT provides against osteoporosis and cardiovascular disease. There are also potential side effects such as abdominal pain, insomnia or, in rare cases, serious liver problems.
Another emerging alternative is elinzanetant (Lynkuet), which not only reduces hot flashes but also improves sleep quality. This drug is currently under consideration for broader approval.
Experts emphasize that, in addition to drug treatments, lifestyle changes – such as avoiding spicy foods, caffeine and alcohol, as well as cognitive-behavioral therapy – remain effective ways to manage symptoms.
Despite advances, specialists warn that many women who could benefit from these treatments still do not have access to or sufficient information about them. /GazetaExpress/
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